Laron Dues 247 - Sport

Laron syndrome (LS), also known as growth hormone insensitivity or growth hormone receptor deficiency (GHRD), is an autosomal recessive disorder characterized by a lack of insulin-like growth factor 1 (IGF-1; somatomedin-C) production in response to growth hormone (GH; hGH; somatotropin). [6] Laron syndrome is a rare form of short stature that results from the body's inability to use growth hormone, a substance produced by the brain's pituitary gland that helps promote growth. Laron’s syndrome (LS) is a rare genetic disorder characterized by insensitivity to growth hormone (GH).

Up to the present time, over 70 mutations of GH receptor (GHR) gene have been identified leading to GH/insulin-like growth factor type 1 (IGF1) signaling pathway defect. Today, there may be between 350 and 500 people with Laron syndrome in the United States, Ecuador, Israel, Croatia, Ireland and other European countries, Longo said.